Publications

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SELECTED RECENT PUBLICATIONS (2014-2019)


***Original research articles***


Keklikoglou, I., Cianciaruso, C., Güç, E., Squadrito, M.L., Spring, L.M., Tazzyman, S., Lambein, L., Poissonnier, A., Ferraro, G.B., Baer, C., Cassará, A., Guichard, A., Iruela-Arispe, M.L., Lewis, C.E., Coussens, L.M., Bardia, A., Jain, R.K., Pollard, J.W., & De Palma, M.

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models.

Nat Cell Biol. 2019 Feb;21(2):190-202.

Highlight: Nat Rev Cancer 2019 (doi: 10.1038/s41568-019-0111-2).

Highlight: F1000Prime (https://f1000.com/prime/734718811).


Neubert, N. J., Schmittnaegel, M., Bordry, N., Nassiri, S., Wald, N., Martignier, C., Tillé, L., Hemicsko, K., Damsky, W., Maby El-Hajjami, H., Klaman, I., Danenberg, E., Ioannidou, K., Kandalaft, L., Coukos, G., Hoves, S., Ries, C. H., Fuertes Marraco, S. A., Foukas, P. G., & De Palma, M., Speiser, D.E.

T cell-induced CSF1 promotes melanoma resistance to PD1 blockade.

Sci Transl Med. 2018 Apr 11;10(436), pii: eaan3311.

Highlight: Cancer Immunol Res. 2018 June 1;6(6):629.


Keklikoglou, I., Kadioglu, E., Bissinger, S., Langlois, B., Bellotti, A., Orend, G., Ries, C.H. & De Palma, M.

Periostin limits tumor response to VEGFA inhibition.

Cell Rep. 2018 Mar;22(10):2530-2540.

Featured Cover Article


Squadrito, M.L., Cianciaruso, C., Hansen, S.K., & De Palma, M.

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens.

Nat Methods. 2018 Mar;15(3):183-186.


Cortesi, F., Delfanti G., Grilli, A., Calcinotto A., Gorini, F., Pucci, F., Lucianò R., Grioni, M., Recchia, A., Benigni, F., Briganti, A., Salonia A., De Palma, M., Bicciato, S., Doglioni, C., Bellone, M., Casorati, G., Dellabona, P.

Bimodal CD40/Fas-dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progression.

Cell Rep. 2018 Mar;22(11):3006-3020.


Hoves, S., Ooi, C.-H., Wolter, C., Sade, H., Bissinger, S., Schmittnaegel, M., Ast, O., Giusti, A.M., Wartha, K., Runza, V., Xu, W., Kienast, Y., Cannarile, M.A., Levitsky, H., Romagnoli, S., De Palma, M., Rüttinger, D., & Ries, C.H.

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity.

J Exp Med. 2018 March 5;215(3):859-876

Highlight: Cancer Immunol Res. 2018 May 1;6(5):501.


Scodeller, P., Simon Gracia, L., Kopanchuk, S., Tobi, A., Kilk, K., Säälik, P., Kurm, K., Squadrito, M.L., Kotamraju, V.R., Rinken, A., De Palma, M., Ruoslahti, E., & Teesalu, T.

Precision targeting of tumor macrophages with a CD206 binding peptide.

Sci Rep 2017Nov 7;7(1):14655.


Harney, S.A., Karagiannis, G.S., Pignatelli, J., Smith, B.D., Kadioglu, E., Wise, S.C., Hood, M.M., Kaufman, M.D., Leary, C.B., Lu, W.-P., Al-Ani, G., Chen, X., Entenberg, D., Oktay, M.H., Wang, Y., Chun, L., De Palma, M., Jones, J.G., Flynn, D.L., & Condeelis, J.S.

The selective Tie2 inhibitor rebastinib blocks recruitment and function of Tie2Hi macrophages in breast cancer and neuroendocrine pancreatic tumors.

Mol Cancer Ther. 2017 Nov 1;16(11):2486-2501.


Schmittnaegel, M., Rigamonti, N., Kadioglu, E., Cassará, A., Wyser Rmili, C., Kiialainen, A., Kienast, Y., Mueller, H.-J., Ooi, C.-H., Laoui, D., and De Palma, M.

Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaak9670.

Highlight: Nat Rev Clin Oncol. 2017 (doi: 10.1038/nrclinonc.2017.6).

Highlight: Nat Rev Drug Discov. 2017 (doi: 10.1038/nrd.2017.103).

Highlight: Nat Rev Rev Cancer 2017 (doi: 10.1038/nrc.2017.39).

Highlight: Science Signal. 2017 (doi: 10.1126/scisignal.aan4458).

Highlight: F1000Prime (https://f1000.com/prime/727504006).

Featured Cover Article


Cianciaruso, C., Phelps, E.A., Pasquier, M., Hamelin, R., Demurtas, D., Alibashe Ahmed, M., Piemonti, L., Hirosue, S., Swartz, M., De Palma, M., Hubbell, J.A., and Baekkeskov, S.

Primary human and rat beta cells release the intracellular autoantigens GAD65, IA-2 and proinsulin in exosomes together with cytokine-induced enhancers of immunity.

Diabetes2017 Feb;66(2):460-473.

Featured Cover Article


He, H., Mack, J., Guc, E., Warren, C., Squadrito, M.L., Kilarski, W., Baer, C., Freshman, R., McDonald, A., Ziyad, S., Swartz, M.A., De Palma, M., and Iruela-Arispe, M.L.

Perivascular Macrophages Limit Permeability.

Arterioscler Thromb Vasc Biol. 2016 Nov;36(11):2203-2212

Featured Cover Article


Baer, C., Squadrito, M.L., Laoui, D., Thompson, D., Hansen, S.K., Kiialainen, A., Hoves, S., Ries, C.H., Ooi, C.-H., De Palma, M.

Suppression of microRNA activity amplifies IFN-γ-induced macrophage activation and promotes anti-tumor immunity.

Nat Cell Biol. 2016 Jul;18(7):790-802.

News & Views (Lee and Biswas): Nat Cell Biol. 2016 Jul;18(7):718-720.


Wallerius, M., Wallmann, T., Bartish, M., Östling, J., Mezheyeuski, A., Tobin, N.P., Nygren, E., Pangigadde, P.N., Pellegrini, P., Squadrito, M.L., Pontén, F., Hartman, J., Bergh, J., De Milito, A., De Palma, M., Ostman, A., Andersson, J., Rolny, C.

Guidance molecule SEMA3A restricts tumor growth by differentially regulating the proliferation of tumor-associated macrophages

Cancer Res. 2016 Jun 1;76(11):3166-78 IF: 9.329


Galletti, G., Scielzo, C., Barbaglio, F., Veliz Rodriguez, T., Riba, M., Lazarevic, D., Cittaro, D., Simonetti, G., Ranghetti, P., Scarfò, L., Ponzoni, M., Rocchi, M., Corti, A., Anselmo, A., van Rooijen, N., Klein, C., Ries, H.C., Ghia, P., De Palma, M., Caligaris-Cappio, F., Bertilaccio, M.T.S.

Targeting macrophages sensitizes chronic lymphocytic leukemia to apoptosis and inhibits disease progression.

Cell Rep. 2016 Feb 23;14(7):1748-60


Heinsbroek, S.E.M., Squadrito, M.L., Schilderink, R., Hilbers, F.W., Verseijden, C., Hofmann, M., Helmke, A., Boon, L., Wildenberg, M.E., Roelofs, J.J.T.H., Ponsioen, C.Y., Peters, C.P., te Velde, A.A., Gordon, S., De Palma, M., & de Jonge, W.J.

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation.

Mucosal Immunol2016 Jul;9(4):960-973.


Ferri, F., Parcelier, A., Petit, V., Gallouet, A.S., Lewandowski, D., Dalloz, M., van den Heuvel, A., Kolovos P., Sole, E., Squadrito, M.L., De Palma, M., Davidson, I., Rousselet, G., & Romeo, P.H.

TRIM33 switches off Ifnb1 gene transcription during the late phase of macrophage activation.

Nat Commun. 2015 Nov 23;6:8900.


Hughes, R., Qian, B.-Z., Muthana, M., Keklikoglou, I., Olson, O.C., Tazzyman, S., Danson, S.J., Addison, C.L., Clemons, M., Gonzalez-Angulo, A.M., Joyce, J.A., De Palma, M., Pollard, J.W., & Lewis, C.E.

Perivascular M2 macrophages stimulate tumor relapse after chemotherapy. 

Cancer Res. 2015 Sep 1;75(17):3479-91.


Keskin, D., Kim, J., Cooke, V.G., Wu, C.C., Sugimoto, H., Gu, C., De Palma, M., Kalluri, R., & LeBleu, V.S.

Targeting vascular pericytes in hypoxic tumors promotes lung metastasis via angiopoetin-2.

Cell Rep. 2015 Feb 24;10(7):1066-81.

Featured Cover Article


Hemmesi, K., Squadrito, M.L., Mestdagh, P., Conti, V., Cominelli, M., Piras, I.S., Sergi Sergi, L., Piccinin, S., Maestro, R., Poliani, P.L., Speleman, F., De Palma, M., & Galli, R.

mir-135a inhibits cancer stem cell-driven medulloblastoma development by directly repressing Arhgef6 expression.

Stem Cells. 2015 May;33(5):1377-89.


Squadrito, M.L., Baer, C., Burdet, F., Maderna, C., Gilfillan, G.D., Lyle, R., Ibberson, M., & De Palma, M.

Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells.

Cell Rep. 2014 Sep 11;8(5):1432-1446.


Rigamonti, N., Kadioglu, E., Keklikoglou, I., Wyser Rmili, C., Leow, C.C., & De Palma, M.

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signalling blockade.

Cell Rep. 2014 Aug 7;8(3):696-706.


Cianciaruso, C., Pagani, A., Martelli, C., Bacigaluppi, M., Squadrito, M.L., Lo Dico, A., De Palma, M., Furlan, R., Lucignani, G., Falini, A., Biffi, A., Ottobrini, L., & Politi, L.S.

Cellular magnetic resonance with iron oxide nanoparticles: long-term persistence of SPIO signal in the CNS after transplanted cell death.

Nanomedicine (Lond). 2014 Jul;9(10):1457-74


Escobar, G., Moi, D., Ranghetti, A., Ozkal-Baydin, P., Squadrito, M.L., Kajaste-Rudnitski, A., Bondanza, A., Gentner, B., De Palma, M., Mazzieri, R., & Naldini, L.

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Sci Transl Med. 2014 Jan 1;6(217):217ra3

Featured Cover Article


***Reviews***


Lapenna, A., De Palma, M. & Lewis, C.E.

Perivascular macrophages in health and disease

Nat Rev Immunol. 2018 Nov;18(11):689-702.


Nowak-Sliwinska, P. et al.

Consensus guidelines for the use and interpretation of angiogenesis assays

Angiogenesis 2018 Aug;21(3):425-532.


Schmittnaegel, M. & De Palma, M.

Reprogramming tumor blood vessels for enhancing immunotherapy

Trends Cancer 2017 Dec;3(12):809-812.

De Palma, M., Biziato, D., & Petrova, T.V.


Microenvironmental regulation of tumour angiogenesis.

Nat Rev Cancer. 2017 Aug;17(8):457-474.


***Editorials***


De Palma, M. & Jain, R.K

CD4+ T cell activation and vascular normalization: Two sides of the same coin?

Immunity2017May 16;46(5):773-775.


De Palma, M.

Origins of brain tumor macrophages.

Cancer Cell. 2016 Dec 12;30(6):832-833.


Squadrito, M.L. & De Palma, M.

DICERing macrophages for reprogramming TAMs.

Cell Cycle. 2016 Dec;15(23):3149-3150.


Kadioglu, E. & De Palma, M.

Cancer metastasis: Perivascular macrophages under watch.

Cancer Discov. 2015 Sep;5(9):906-8.


Squadrito, M.L. & De Palma, M.

A niche role for periostin and macrophages in glioblastoma.

Nat Cell Biol 2015 Jan 30;17(2):107-9.


Biziato, D. & De Palma, M.

Assessing metastasis risk after pre-operative anti-angiogenic therapy.

EMBO Mol Med. 2014 Dec12;6(12):1515-7.


Keklikoglou, I. & De Palma, M.

Cancer: Metastasis risk after anti-macrophage therapy.

Nature. 2014 Nov 6;515(7525):46-7.



EPFL PATENTS

Title: Engineered antigen-presenting cells and uses thereof.

Inventors: Michele DE PALMA, Mario Leonardo SQUADRITO

Applicant: EPFL

Publication number: WO2017134100 A1; Application number: PCT/EP2017/052145

Publication date: Aug 10, 2017; Filing date: Feb 1, 2017; Priority date: Feb 2, 2016